Epigenetics in Psychiatry

Epigenetics in Psychiatry

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Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discoveryDNMT3 proteins interact with HDACs through the plant homeodomain (PHD) in the N-terminal region (Figure 24.2). The interaction of DNMT proteins with chromatin modifiers implies that DNMT-mediated transcriptional repression involves theanbsp;...


Title:Epigenetics in Psychiatry
Author: Jacob Peedicayil, Dennis R. Grayson, Dimitri Avramopoulos
Publisher:Elsevier - 2014-06-23
ISBN-13:

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